Table 1 Demographic characteristics and gene expression of the cohorts

From: Gene expression over the course of schizophrenia: from clinical high-risk for psychosis to chronic stages

 

HCs

CHR

FEP

SZ

P value

Gender (%)

M: 73 (52.1)

M: 17 (63)

M: 42 (60)

M: 100 (63.7)

0.226a

F: 67 (47.9)

F: 10 (37)

F: 28 (40)

F: 57 (36.3)

Age in years (SD)

33.51 (11.94)

18.00 (3.27)

25.86 (7.49)

38.65 (10.82)

<0.001b

COMT (SD)c

5.62 (0.31)

5.60 (0.34)

5.74 (0.33)

5.55 (0.37)

0.112d

TNF (SD)c

7.01 (0.45)

7.19 (0.35)

7.18 (0.51)

6.85 (0.50)

0.372d

AKT1 (SD)c

4.32 (0.27)

4.31 (0.28)

4.33 (0.34)

4.30 (0.30)

1.000d

MBP (SD)c

8.79 (0.63)

9.29 (0.92)

8.42 (0.76)

8.93 (0.54)

<0.001 d

DGCR8 (SD)c

7.05 (0.43)

7.00 (0.41)

7.30 (0.53)

7.17 (0.47)

0.031 d

DICER1 (SD)c

5.52 (0.37)

5.53 (0.43)

5.49 (0.41)

5.42 (0.39)

1.000d

DROSHA (SD)c

6.60 (0.42)

6.47 (0.60)

6.85 (0.54)

6.65 (0.44)

0.056d

DGCR2 (SD)c

4.72 (0.42)

4.60 (0.40)

4.54 (0.35)

4.94 (0.41)

<0.001 d

UFD1 (SD)c

7.29 (0.51)

7.07 (0.40)

7.51 (0.45)

6.98 (0.47)

<0.001 d

DISC1 (SD)c

8.66 (0.69)

8.15 (0.73)

8.62 (0.68)

8.37 (0.88)

0.005 d

NDEL1 (SD)c

4.07 (0.32)

4.12 (0.41)

3.79 (0.40)

4.06 (0.38)

<0.001 d

PAFAH1B1 (SD)c

4.74 (0.25)

4.71 (0.30)

4.84 (0.31)

4.70 (0.29)

0.133d

  1. HC healthy controls, CHR clinical high risk, FEP first episode of psychosis, CSZ chronic schizophrenia, M male, F female
  2. Bold values mean that the p-value are statistically significant considering a alpha <0.05
  3. aP- value from Pearson’s chi-squared test comparing the four groups
  4. bP value from analysis of variance (ANOVA) test comparing the four groups
  5. cMean presented in ΔCrt which is negatively correlated with gene expression
  6. dP value from general linear model (GLM) comparing the four groups. ΔCrt was inserted as dependent variable, group and gender as fixed factors, and age as covariate. Bonferroni correction for 12 comparisons was applied
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