Table 2 Group differences in DTI measures of brain white matter tract integrity

From: Impaired illness awareness in schizophrenia and posterior corpus callosal white matter tract integrity

 

Imp-IA (n = 40)

Int-IA (n = 60)

HC (n = 134)

Statistic Test (df)

p value

Mean

SD

Mean

SD

Mean

SD

  

Average FA

A priori region of interest

 Splenium (SCC)

0.678

0.046

0.692

0.031

0.694

0.034

F(2, 231) = 3.09; ANOVA

0.047*a

Other white matter tracts

     

F(32, 432) = 0.97; MANOVA

0.518

Other corpus callosal tracts

  

 BCC

0.572

0.056

0.589

0.040

0.591

0.048

  

 GCC

0.622

0.051

0.642

0.039

0.636

0.044

 Whole CC

0.618

0.049

0.635

0.033

0.635

0.039

Other white matter tracts previously associated with SCZ

 ALIC_L

0.517

0.035

0.527

0.035

0.528

0.034

 ALIC_R

0.514

0.039

0.529

0.031

0.527

0.030

 CGC_L

0.510

0.054

0.517

0.036

0.519

0.042

 CGC_R

0.470

0.045

0.478

0.037

0.481

0.039

 CGH_L

0.435

0.046

0.451

0.055

0.442

0.047

 CGH_R

0.421

0.043

0.439

0.049

0.431

0.050

 PLIC_L

0.658

0.029

0.655

0.029

0.653

0.030

 PLIC_R

0.649

0.028

0.647

0.024

0.644

0.028

 RLIC_L

0.540

0.037

0.553

0.032

0.553

0.034

 RLIC_R

0.522

0.032

0.531

0.035

0.527

0.034

 UNC_L

0.474

0.058

0.487

0.052

0.492

0.058

 UNC_R

0.488

0.053

0.499

0.053

0.497

0.060

 Whole brain

0.379

0.024

0.386

0.019

0.386

0.020

Average MD

A priori region of interest

SCC

0.00246

0.00020

0.00247

0.00018

0.00242

0.00020

F(2, 231) = 1.82; ANOVA

0.164

Other white matter tracts

F(32, 432) = 1.24; MANOVA

0.174

Other corpus callosal tracts

  

 BCC

0.00198

0.00037

0.00198

0.00028

0.00193

0.00033

  

 GCC

0.00202

0.00047

0.00195

0.00035

0.00188

0.00040

 Whole CC

0.00214

0.00033

0.00213

0.00025

0.00207

0.00029

Other white matter tracts previously associated with SCZ

 ALIC_L

0.00176

0.00068

0.00169

0.00053

0.00165

0.00060

 ALIC_R

0.00170

0.00067

0.00156

0.00055

0.0015

0.00056

 CGC_L

0.00104

0.00013

0.00101

0.00008

0.00101

0.00011

 CGC_R

0.00101

0.00010

0.00098

0.00008

0.00098

0.00009

 CGH_L

0.00290

0.00026

0.00288

0.00034

0.00283

0.00030

 CGH_R

0.00274

0.00032

0.00282

0.00035

0.00267

0.00030

 PLIC_L

0.00098

0.00011

0.00097

0.00008

0.00096

0.00010

 PLIC_R

0.00093

0.00009

0.00092

0.00008

0.00091

0.00009

 RLIC_L

0.00149

0.00030

0.00143

0.00025

0.00141

0.00027

 RLIC_R

0.00150

0.00029

0.00146

0.00026

0.00142

0.00026

 UNC_L

0.00292

0.0003

0.00296

0.00029

0.00291

0.00031

 UNC_R

0.00278

0.00033

0.00284

0.00034

0.00271

0.00036

 Whole brain

0.00143

0.00019

0.00140

0.00014

0.00137

0.00016

  1. ALIC Anterior limb of internal capsule; ANOVA Analysis of variance; BCC Body of corpus callosum; CGC Cingulum (cingulate gyrus); CGH Cingulum (hippocampus); CC Corpus callosum; df Degrees of freedom (between groups, within groups); FA Fractional anisotropy; GCC Genu of corpus callosum; HC Healthy controls; Imp-IA Impaired illness awareness; Int-IA Intact illness awareness; L Left hemisphere; MANOVA Multivariate analysis of variance; MD Mean diffusivity; PLIC Posterior limb of internal capsule; R Right hemisphere; RLIC Retrolenticular part of internal capsule; SCC Splenium of corpus callosum; SD Standard deviation; SCZ Schizophrenia; UNC Uncinate fasciculus
  2. *p < 0.05 after controlling for covariates and Bonferroni adjustments for multiple comparisons: age, sex, education, premorbid intelligence, and global cognition
  3. aPost hoc Bonferroni significant group differences between Imp-IA & HC
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