Fig. 2: Augmenting \({\bar{g}}_{{\rm{NMDAR}}}\) on OLM interneurons.
From: In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia
a Information transfer (nTE) and modulation index (MI) showed an inverted-U relationship with scaling OLM \({\bar{g}}_{{\rm{NMDAR}}}\) up (mean ± SEM). b Increasing OLM \({\bar{g}}_{{\rm{NMDAR}}}\) increased activity of OLM interneurons (blue), reduced pyramidal (red) and PV (green) neuronal firing, and reduced gamma power (mean ± SEM). c Inverted-U relationship between gamma power and information flow shown with different levels of OLM \({\bar{g}}_{{\rm{NMDAR}}}\) (mean ± SEM). Note that highest \({\bar{g}}_{{\rm{NMDAR}}}\) is now at the left (values in shaded rectangles). d Raster plots and LFP at different \({\bar{g}}_{{\rm{NMDAR}}}\) scaling relative to control.
