Fig. 8: Schematic diagram for the in silico CA3 network model showing targets for multi-drug target manipulations.
From: In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia
Population of pyramidal neurons (n = 800) is represented by the red cell, PV basket interneurons (n = 200) by the green cell, and OLM interneurons (n = 200) by the blue cell. Dotted lines represent the random input driving the pyramidal neuron population (driving inputs). Output represents the spiking output of pyramidal neurons. MS is medial septum, providing inhibitory input onto the PV basket and OLM interneurons. Numbers on connections are convergence ratios for connectivity between different populations. Cyan boxes show the molecular targets that are being investigated in this study and their locations: \({\bar{g}}_{{\rm{NMDAR}}}\) on OLM interneurons, \({\bar{g}}_{{{\rm{GABA}}}_{{\mathrm{A}}}{\rm{R}}}\) on pyramidal neurons, and \(\bar{g}_{\rm{h}}\) on pyramidal neurons and PV basket interneurons. Activation and inactivation time constants for each of the receptor types are shown.
