Fig. 2: PRS-by-trait quantile plots (in green) indicating the trends of association between the best-fit schizophrenia PRS and the target behavioural traits among 20 of the most significant associations, matching those of Fig. 1.

The quantile plot is ordered along the x-axis from low to high genetic risk for schizophrenia, according to PRS in the target (UK Biobank) data, with each green point representing the average target trait value of a 5% quantile of the sample. The y-axis shows the regression coefficients corresponding to the effects of the PRS on the trait, controlled for covariates (see Methods). Non-medicated (blue) and medicated (red), at baseline, diagnosed individuals are appended to the right end of each plot, reflecting the expected higher genetic burden of diagnosed individuals compared to unaffected individuals (see Main Text). Vertical lines represent 95% confidence intervals; these appear absent for some traits with a large range and are larger in the two categories of cases due to their smaller sample sizes.