Table 4 Changes in cannabis craving, withdrawal and psychiatric symptoms from baseline to Day 28 in active compared to sham treatment.

From: Investigating repetitive transcranial magnetic stimulation on cannabis use and cognition in people with schizophrenia

Outcome

Linear contrast test

Average trajectory difference: interaction test

Treatment * Time

Treatment

Time

MCQ-SV

Estimate = 9.34, df(81.90), p = 0.190

F = 0.81, df(81.81), p = 0.549

F = 0.25, df(16.74), p = 0.624

F = 3.48, df(81.81), p = 0.007*

MCQ1

Estimate = 1.92, df(81.53), p = 0.334

F = 0.50, df(81.40), p = 0.773

F = 0.45, df(16.32), p = 0.513

F = 2.59, df(81.40), p = 0.031*

MCQ2

Estimate = 1.88, df(81.89), p = 0.405

F = 0.84, df(81.77), p = 0.525

F = 0.15, df(16.68), p = 0.706

F = 3.01, df(81.77), p = 0.015*

MCQ3

Estimate = 3.92, df(82), p = 0.064

F = 2.03, df(81.91), p = 0.084

F = 0.003, df(16.84), p = 0.960

F = 3.11, df(81.91), p = 0.013*

MCQ4

Estimate = 1.52, df(82.09), p = 0.484

F = 0.67, df(81.99), p = 0.646

F = 0.73, df(16.91), p = 0.406

F = 1.97, df(81.99), p = 0.091

MWC

Estimate = −1.10, df(82.18), p = 0.586

F = 1.17, df(82.10), p = 0.330

F = 2.67, df(17.03), p = 0.121

F = 5.23, df(82.10), p < 0.0001*

PANSS (Positive)

Estimate = 2.42, df(80.10), p = 0.018*

F = 2.05, df(80.08), p = 0.080

F = 1.39, df(17.02), p = 0.255

F = 2.09, df(80.08), p = 0.076

PANSS (Negative)

Estimate = 1.39, df(80.07), p = 0.297

F = 0.27, df(80.05), p = 0.930

F = 0.19, df(16.96), p = 0.665

F = 0.72, df(80.05), p = 0.612

PANSS (General)

Estimate = 1.20, df(79.94), p = 0.321

F = 2.14, df(79.93), p = 0.069

F = 0.45, df(16.87), p = 0.513

F = 0.76, df(79.93), p = 0.582

PANSS Total

Estimate = 5.03, df(80.07), p = 0.019*

F = 2.79, df(80.06), p = 0.023*

F = 1.14, df(17), p = 0.301

F = 2.21, df(80.06), p = 0.061

CDSS

Estimate = 0.81, df(82.15), p = 0.327

F = 2.15, df(82.08), p = 0.068

F = 0.13, df(17.01), p = 0.726

F = 0.65, df(82.08), p = 0.651

  1. Outliers flagged by boxplot analysis of residuals were removed and the linear contrast and interaction tests were rerun. Contrast estimates for the linear contrast indicate differences in changes of the outcome from Baseline to Day 28 in the active compared to sham group.
  2. CDSS Calgary Depression Scale for Schizophrenia, MCQ Marijuana Craving Questionnaire, MWC Marijuana Withdrawal Checklist, PANSS Positive and Negative Syndrome Scale.
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