Fig. 5: Flowchart of the research. | Schizophrenia

Fig. 5: Flowchart of the research.

From: Reduced erythrocyte membrane polyunsaturated fatty acid levels indicate diminished treatment response in patients with multi- versus first-episode schizophrenia

Fig. 5

Through eligibility assessment, 327 schizophrenia patients and 159 healthy controls were recruited. The recruited patients were divided into four subgroups according to episodes: first episode (FE), 2–3 episodes, 4–6 episodes, and over 6 episodes. We measured the concentrations of ten fatty acids in the erythrocyte membrane and performed PANSS assessment at baseline (SZ-0) and after four weeks of treatment (SZ-4). Total and subgroup analyses were conducted to identify differential biomarkers between schizophrenia patients and healthy controls. Correlations between fatty acid level changes and symptom improvement were analyzed by partial correlation analysis and logistic regression, to explore potential biomarkers indicative of treatment responsiveness.

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