Fig. 1: Longitudinal pattern of niacin-induced flush.

Mean niacin flush score that was summed over the three concentrations for ratings at 5, 10, and 15 min, respectively, at different time points in a healthy controls and b schizophrenia patients, with error bars representing standard error. Time 1 = baseline, time 2 = week 2, time 3 = week 4, and time 4 = week 8 or on the first outpatient follow-up if the patient had been discharged by 8 weeks. Solid lines represent the scores of all participants who had flush scores at both time 1 and time 4 (n = 37 for controls and 46 for schizophrenia) and dashed lines the scores of a subgroup of participants who had flush scores at all four time points (n = 22 for controls and 35 for schizophrenia). For those summed niacin flush scores that changed significantly with time in a mixed-effects model were denoted with p values.