Table 2 Results of the mediation analysis of selected clinical and cognitive variables in the association between EEAA DNAmTL and relapse.

From: Epigenetic clocks in relapse after a first episode of schizophrenia

Mediator

Direct Effect1 Estimate (95% CI) p-value

Total Effect2 Estimate (95% CI) p-value

Indirect Effect3 Estimate (95% CI) p-value

Working memory

−0.44 (−0.54, −0.24) 0.024

−0.44 (−0.54, −0.24) 0.020

−0.09 (−0.33, 0.26) 0.540

Verbal fluency

−0.45 (−0.55, −0.18) 0.040

−0.45 (−0.56, −0.26) 0.016

−0.08 (−0.34, 0.21) 0.604

  1. 1The effect of EEAA DNAmTL on relapse with the effect of the mediator.
  2. 2The effect of EEAA DNAmTL on relapse without the mediator.
  3. 3The total effect minus the direct effect.
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