Table 1 Demographics of Sample at Index Date and Utilization and Outcomes from Index Date to 6 Months of F/U, by Outcome (Relapse) Status.

 Schizophrenia

4337 (53.42%)

1233 (28.43%)

3104 (71.57%)

REF

–

 Schizoaffective

3712 (45.72%)

1206 (32.49%)

2506 (67.51%)

1.14 (1.07, 1.22)

<0.0001

 Both^

70 (0.86%)

39 (55.71%)

31 (44.29%)

 Private

889 (10.95%)

206 (23.17%)

683 (76.83%)

REF

–

 Medicare

4173 (51.40%)

1121 (26.86%)

3052 (73.14%)

1.16 (1.02, 1.32)

0.0256

 Medicaid

2761 (34.01%)

1072 (38.83%)

1689 (61.17%)

1.68 (1.47, 1.91)

<0.0001

 Other

296 (3.65%)

79 (26.69%)

217 (73.31%)

1.15 (0.92, 1.44)

0.2154

 Female

3676 (45.28%)

1114 (30.30%)

2562 (69.70%)

REF

–

 Male

4443 (54.72%)

1364 (30.70%)

3079 (69.30%)

1.01 (0.94, 1.10)

0.7483

 White, Non-Hispanic or Latino

4383 (54.23%)

1206 (27.52%)

3177 (72.48%)

REF

-

 Black, Non-Hispanic or Latino

2653 (32.83%)

920 (34.68%)

1733 (65.32%)

1.26 (1.17, 1.35)

<0.0001

 Asian, Non-Hispanic or Latino

166 (2.05%)

44 (26.51%)

122 (73.49%)

0.96 (0.74, 1.30)

0.8076

 American Indian or Alaskan Native, Non-Hispanic or Latino

95 (1.18%)

23 (24.21%)

72 (75.79%)

0.88 (0.58, 1.33)

0.5433

 Other Pacific Islander, Non-Hispanic or Latino

12 (0.15%)

7 (58.33%)

5 (41.67%)

2.12 (1.01, 4.46)

0.0474

 Two or more races, Non-Hispanic or Latino

114 (1.41%)

45 (39.47%)

69 (60.53%)

1.43 (1.07, 1.93)

0.0175

 Hispanic or Latino

659 (8.15%)

233 (35.36%)

426 (64.64%)

1.29 (1.12, 1.48)

0.0005

 Outpatient

4273 (52.63%)

968 (22.65%)

3305 (77.35%)

REF

–

 Inpatient

188 (2.32%)

104 (55.32%)

84 (44.68%)

2.44 (2.12, 2.81)

<0.0001

 Emergency Room

855 (10.53%)

470 (54.97%)

385 (45.03%)

2.43 (2.23, 2.63)

<0.0001

 Behavioral Health

2803 (34.52%)

936 (33.39%)

1867 (66.61%)

1.47 (1.37, 1.59)

<0.0001

 Behavioral Health Other

2272 (81.06%)

561 (24.69%)

1711 (75.31%)

REF

REF

 Behavioral Health Inpatient

531 (18.94%)

375 (70.62%)

156 (29.38%)

2.86 (2.61, 3.13)

<0.0001

Age (Mean (SD); Median (IQR))^#

47.45 (15.66); 49 (35–59)

44.67 (15.35); 45 (32–56)

48.67 (15.64); 51 (36–60)

−4.00 (−4.72, −3.27)

<0.0001

 0–17

99 (1.22%)

28 (28.28%)

71 (71.72%)

REF

–

 18–64

6895 (84.92%)

2201 (31.92%)

4694 (68.08%)

1.44 (1.29, 1.62)

<0.0001

 65+

1125 (13.86%)

249 (22.13%)

876 (77.87%)

1.13 (0.82, 1.55)

0.4522

 Substance Use

1562 (19.24%)

725 (46.41%)

837 (53.59%)

1.74 (1.62, 1.86)

<0.0001

 Overweight/Obesity/Weight Gain

1060 (13.06%)

270 (25.47%)

790 (74.53%)

0.81 (0.73, 0.91)

0.0002

 EPS

3897 (48.00%)

1660 (42.60%)

2237 (57.40%)

2.20 (2.05, 2.36)

<0.0001

 Disorders of lipid metabolism

2489 (30.66%)

649 (26.07%)

1840 (73.93%)

0.80 (0.74, 0.87)

<0.0001

 Hypertension

2180 (26.85%)

578 (26.51%)

1602 (73.49%)

0.83 (0.77, 0.90)

<0.0001

 Diabetes

1549 (19.08%)

427 (27.57%)

1122 (72.43%)

0.88 (0.81, 0.96)

0.0058

Total Follow-up (Months)

27.99 (7.60); 31 (22–35)

28.84 (7.38); 32 (23–35)

27.62 (7.67); 30 (22–35)

1.22 (0.87, 1.57)

<0.0001

 Outpatient

6.81 (10.30); 4 (1–8)

7.81 (12.41); 4 (1–9)

6.38 (9.19); 4 (1–8)

1.43 (0.89, 1.97)

0.1876

 Inpatient

0.16 (0.56); 0 (0–0)

0.24 (0.69); 0 (0–0)

0.13 (0.49); 0 (0–0)

0.11 (0.08, 0.14)

<0.0001

 Emergency Room

0.97 (3.22); 0 (0–1)

2.13 (4.98); 1 (0–2)

0.45 (1.78); 0 (0–0)

1.68 (1.48, 1.88)

<0.0001

 Behavioral Health

2.00 (4.61); 0 (0–2)

2.80 (6.12); 1 (0–3)

1.65 (3.70); 0 (0–2)

1.15 (0.89, 1.41)

<0.0001

 Behavioral Health Inpatient

0.18 (0.65); 0 (0–0)

0.46 (1.02); 0 (0–1)

0.06 (0.33); 0 (0–0)

0.39 (0.35, 0.43)

<0.0001

 Behavioral Health Other

1.82 (4.48); 0 (0-2)

2.35 (5.91); 0 (0–2)

1.59 (3.65); 0 (0–2)

0.76 (0.51, 1.01)

0.4917

 Prior Relapse Episodes

0.52 (1.71); 0 (0–0)

1.31 (2.67); 0 (0–1)

0.17 (0.83); 0 (0–0)

1.14 (1.03, 1.25)

<0.0001

 Care Escalation Episodes

1.40 (3.51); 0 (0–1)

2.50 (4.91); 1 (0–3)

0.92 (2.52); 0 (0–1)

1.58 (1.37, 1.78)

<0.0001

 Medication Switch Episodes

0.24 (0.71); 0 (0–0)

0.51 (1.03); 0 (0–1)

0.12 (0.46); 0 (0–0)

0.39 (0.34, 0.43)

<0.0001

 Medication Addition Episodes

0.21 (0.65); 0 (0–0)

0.44 (0.97); 0 (0–1)

0.10 (0.41); 0 (0–0)

0.34 (0.30, 0.38)

<0.0001

 Anticholinergics

1.24 (4.87); 0 (0–0)

2.27 (6.47); 0 (0–2)

0.79 (3.88); 0 (0–0)

1.48 (1.20, 1.75)

<0.0001

 Antidepressants

2.95 (7.49); 0 (0–2)

4.80 (9.69); 0 (0–5)

2.15 (6.12); 0 (0–1)

2.65 (2.24, 3.06)

<0.0001

 Anticonvulsants

3.55 (9.53); 0 (0–2)

5.50 (12.12); 0 (0–5)

2.70 (7.98); 0 (0–1)

2.81 (2.28, 3.33)

<0.0001

 Anti-parkinson

1.19 (4.55); 0 (0–0)

2.21 (6.22); 0 (0-2)

0.75 (3.48); 0 (0–0)

1.46 (1.20, 1.72)

<0.0001

 Anxiolytics

2.31 (6.49); 0 (0–2)

4.03 (8.54); 1 (0–4)

1.55 (5.17); 0 (0–0)

2.48 (2.11, 2.84)

<0.0001

 Mood stabilizers

0.68 (3.70); 0 (0–0)

1.21 (5.38); 0 (0–0)

0.45 (2.61); 0 (0–0)

0.75 (0.53, 0.97)

<0.0001

 Typical antipsychotics

1.04 (3.81); 0 (0–0)

1.92 (5.32); 0 (0–2)

0.66 (2.82); 0 (0–0)

1.26 (1.04, 1.48)

<0.0001

 Atypical antipsychotics

4.24 (8.65); 1 (0–5)

6.77 (11.41); 3 (0–8)

3.13 (6.82); 0 (0–4)

3.63 (3.23, 4.03)

<0.0001

 LAI antipsychotics

0.14 (1.51); 0 (0–0)

0.23 (2.27); 0 (0–0)

0.10 (1.01); 0 (0–0)

0.13 (0.03, 0.22)

0.0006