Fig. 3: Summary of brain regions and white matter tracts most frequently associated with depressive symptoms in SSDs, based on 11 T1-weighted sMRI and 4 dMRI studies.

The color scale corresponds to the frequency of the region or tract reported. A A schematic illustration of regions implicated in depressive symptoms in SSDs. Subcortical regions are shown through a glass brain, and cortical regions are displayed on the cerebral cortex, as per the Desikan-Killiany Cortical Atlas parcellation. Top regions include the bilateral hippocampus, as well as the right frontal areas. Implicated regions are further subdivided into positive (B) and negative (C) associations with depressive symptoms. D A schematic illustration of tracts implicated in depressive symptoms in SSDs. Tracts are shown overlaid on a glass brain, as per the O’Donnell Research Group Fiber Clustering White Matter Atlas parcellation. CC Corpus Callosum, CR Corona Radiata, sFOF Superior Fronto-Occipital Fasciculus, SLF Superior Longitudinal Fasciculus and ThalR Thalamic Radiation. Top tracts include CR, ThalR, and SLF. Note that association and projection tracts are displayed in the left hemisphere, and only the genus of the CC is shown for clarity. Both dMRI studies found positive correlations between white matter tract integrity and depressive symptoms.