Fig. 2: A significant canonical mode between brain-behavior profiles and corresponding cross-loadings with the threshold at ± 0.20 in the FES sample. | Schizophrenia

Fig. 2: A significant canonical mode between brain-behavior profiles and corresponding cross-loadings with the threshold at ± 0.20 in the FES sample.

From: Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia

Fig. 2

A We identified a significant canonical mode between CT/SV neuroanatomic features and cognitive domains in drug-naïve individuals with FES using an sCCA algorithm. Cross-loadings, representing univariate correlation coefficients between each latent variate and the opposite item variables, were extracted at a threshold of ±0.20. We demonstrate cross-loadings between (B) the cognitive variate and CT item variables, (C) between the cognitive variate and SV item variables, and (D) between the neuroanatomic variate and cognitive item variables, for the significant canonical mode in FES individuals. CT cortical thickness, L the left hemisphere, FES first-episode with schizophrenia, p p-value generated in the permutation test, R the right hemisphere, sCCA sparse canonical correlation analysis, sCCA r the coefficient for the significant canonical correlation, SV subcortical volume.

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