Fig. 4: The second significant canonical mode (LV-2) between brain-behavior profiles and corresponding cross-loadings with the threshold at ±0.20 in the antipsychotic-treated sample. | Schizophrenia

Fig. 4: The second significant canonical mode (LV-2) between brain-behavior profiles and corresponding cross-loadings with the threshold at ±0.20 in the antipsychotic-treated sample.

From: Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia

Fig. 4

A We identified two significant canonical modes between CSA/SV neuroanatomic features and cognitive domains in antipsychotic-treated individuals with schizophrenia using an sCCA algorithm and demonstrated the second one in this figure. Cross-loadings, representing univariate correlation coefficients between each latent variate and the opposite item variables, were extracted at a threshold of ±0.20. We demonstrate cross-loadings between (B) the cognitive variate and CSA item variables, (C) between the cognitive variate and SV item variables, and (D) between the neuroanatomic variate and cognitive item variables, for the second significant canonical mode in antipsychotic-treated individuals with schizophrenia. CSA cortical surface area, L the left hemisphere, p p-value generated in permutation tests, R the right hemisphere, sCCA sparse canonical correlation analysis, sCCA r the coefficient for the significant canonical correlation, SV subcortical volume.

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