Table 1 Cross-sample comparisons in demographics and clinical profiles for two samples of individuals with schizophrenia.

From: Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia

Measure

Drug-naïve FES sample (N = 59)

Antipsychotic-treated sample (N = 115)

t/χ2

p-value

Age (M [SD], years)

28.46 (9.24)

45.95 (7.10)

−12.73

<0.001

Sex (Female, N/N%)

31 (52.5%)

41 (35.7%)

4.59

0.032

Education level (M [SD], years)

11.05 (3.40)

10.15 (3.10)

1.71

0.090

Illness duration (M [SD], months)

20.07 (37.44)

229.26 (106.53)

−18.84

<0.001

Length of current hospitalization (M [SD], days)

NA

704.02 (1020.71)

NA

NA

Total length of hospitalization (M [SD], days)

NA

1433.49 (1016.71)

NA

NA

Number of lifetime hospitalization (M [SD])

NA

6.52 (6.24)

NA

NA

CPZ equivalent (M [SD], mg/day)

NA

559.20 (312.33)

NA

NA

Antipsychotic type (n/%)

NA

NA

NA

NA

Typical antipsychotics

NA

11 (9.6%)

NA

NA

Atypical antipsychotics

NA

79 (68.7%)

NA

NA

Mixed types of antipsychotics

NA

20 (17.4%)

NA

NA

Not available

NA

5 (4.3%)

NA

NA

PANSS (M [SD])

NA

NA

NA

NA

Positive score

24.93 (3.61)

10.61 (4.74)

22.06

<0.001

Negative score

23.22 (4.71)

16.04 (5.45)

8.97

<0.001

General psychopathological score

48.32 (6.68)

25.79 (6.07)

21.61

<0.001

Total score

96.47 (11.39)

52.44 (13.88)

22.25

<0.001

GAF (M [SD])

50.25 (15.24)

59.53 (14.85)

−3.82

<0.001

  1. The p values generated for between-sample comparisons of PANSS scores were corrected by false discovery rate (FDR). Boldface indicates p < 0.05.
  2. CPZ chlorpromazine equivalent used to estimate the daily dose of antipsychotics, GAF Global Assessment of Functioning, M mean value, PANSS Positive and Negative Syndrome Scale, SD standard deviation, t t statistic in the two-sample t-test, χ2 chi-square statistic.