Table 3 GO enrichment results of 29 hub targets.

From: Exploration on the potential efficacy and mechanism of methyl salicylate glycosides in the treatment of schizophrenia based on bioinformatics, molecular docking and dynamics simulation

Category

Term

pvalue

Genes

Fold Enrichment

Bonferroni

Benjamini

FDR

GOTERM_BP_DIRECT

GO0071805~potassium ion transmembrane transport

1.21E−06

KCNV1, KCNC2, KCNA1, KCNA2, SLC17A6, KCNQ5

30.201

0.001

0

0

GOTERM_BP_DIRECT

GO0034765~regulation of ion transmembrane transport

1.26E−06

KCNV1, KCNC2, KCNA1, KCNA2, KCNQ5, SCN1A

29.975

0.001

0

0

GOTERM_BP_DIRECT

GO0099505~regulation of presynaptic membrane potential

1.06E−05

KCNC2, KCNA1, KCNA2, SCN1A

89.26

0.008

0.003

0.003

GOTERM_BP_DIRECT

GO0010629~negative regulation of gene expression

7.20E−05

RB1, TGFB2, GJA1, FBXW7, APOE, VEGFA

12.999

0.055

0.014

0.014

GOTERM_CC_DIRECT

GO:0030424~axon

1.83E−08

TGFB2, MAPK8, KCNC2, BDNF, DCTN1, KCNA2, NEFH, PVALB, SCN1A

17.779

0

0

0

GOTERM_CC_DIRECT

GO:0008076~voltage-gated potassium channel complex

4.21E−06

KCNV1, KCNC2, KCNA1, KCNA2, KCNQ5

43.9

0.001

0

0

GOTERM_CC_DIRECT

GO:0098982 ~ GABA-ergic synapse

5.10E−06

NLGN1, KCNC2, SST, ATP2B2, PLCB1

41.834

0.001

0

0

GOTERM_CC_DIRECT

GO:0045202~synapse

5.74E−06

CAMK2B, NLGN1, MAPK8, KCNC2, SST, KCNA1, KCNA2, PVALB

10.595

0.001

0

0

GOTERM_CC_DIRECT

GO:0043025~neuronal cell body

8.25E−06

TGFB2, DCTN1, SST, KCNA1, APOE, PVALB, SCN1A

13.565

0.001

0

0

GOTERM_CC_DIRECT

GO:0098978~glutamatergic synapse

1.57E−05

GRIN2A, NLGN1, KCNA1, KCNA2, ATP2B2, APOE, PLCB1

12.112

0.003

0

0

GOTERM_CC_DIRECT

GO:0045211~postsynaptic membrane

1.44E−04

GRIN2A, NLGN1, KCNC2, KCNA1, KCNA2

17.869

0.024

0.003

0.003

GOTERM_CC_DIRECT

GO:0030425~dendrite

3.08E−04

NLGN1, KCNC2, BDNF, KCNA1, KCNA2, APOE

9.525

0.05

0.006

0.006

GOTERM_CC_DIRECT

GO:0043194~axon initial segment

3.67E−04

KCNA1, KCNA2, SCN1A

101.596

0.06

0.007

0.006

GOTERM_CC_DIRECT

GO:0005887~integral component of plasma membrane

4.82E−04

KCNV1, GRIN2A, NLGN1, GJA1, KCNC2, KCNA1, KCNA2, ATP2B2, KCNQ5

4.451

0.078

0.008

0.008

GOTERM_CC_DIRECT

GO:0042734~presynaptic membrane

6.68E−04

GRIN2A, KCNC2, KCNA1, KCNA2

22.399

0.106

0.01

0.009

GOTERM_CC_DIRECT

GO:0032809~neuronal cell body membrane

7.05E−04

KCNC2, KCNA2, ATP2B2

73.57

0.112

0.01

0.009

GOTERM_CC_DIRECT

GO:0043005~neuron projection

0.001455

CAMK2B, GRIN2A, DCTN1, KCNA2, SLC17A6

9.663

0.217

0.019

0.018

GOTERM_MF_DIRECT

GO:0099508~voltage-gated ion channel activity involved in regulation of presynaptic membrane potential

4.73E−07

KCNC2, KCNA1, KCNA2, SCN1A

237.555

0

0

0

GOTERM_MF_DIRECT

GO:0005249~voltage-gated potassium channel activity

2.28E−06

KCNV1, KCNC2, KCNA1, KCNA2, KCNQ5

51.037

0

0

0

GOTERM_MF_DIRECT

GO:0005251~delayed rectifier potassium channel activity

1.68E−05

KCNC2, KCNA1, KCNA2, KCNQ5

76.856

0.003

0.001

0.001

GOTERM_MF_DIRECT

GO:0005516~calmodulin binding

2.31E−04

CAMK2B, RGS4, ATP2B2, KCNQ5, PLCB1

15.78

0.034

0.008

0.008

GOTERM_MF_DIRECT

GO:0001540~beta-amyloid binding

2.63E−04

TGFB2, GRIN2A, NLGN1, APOE

30.742

0.039

0.008

0.008

GOTERM_MF_DIRECT

GO:0005267~potassium channel activity

0.001359

KCNA1, KCNA2, KCNQ5

52.968

0.187

0.034

0.033

GOTERM_MF_DIRECT

GO:0019899~enzyme binding

0.002229

DAOA, RB1, MAPK8, APOE, PLCB1

8.596

0.288

0.048

0.046

GOTERM_MF_DIRECT

GO:0042802~identical protein binding

0.002543

CAMK2B, RB1, NLGN1, SST, FBXW7, APOE, PLCB1, PVALB, VEGFA

3.45

0.321

0.048

0.046

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