Fig. 1: Differences in cerebral blood flow in treatment-resistant schizophrenia prior to clozapine initiation (N = 36) compared to healthy volunteers (N = 16). | Schizophrenia

Fig. 1: Differences in cerebral blood flow in treatment-resistant schizophrenia prior to clozapine initiation (N = 36) compared to healthy volunteers (N = 16).

From: Response to clozapine in treatment resistant schizophrenia is related to alterations in regional cerebral blood flow

Fig. 1

Left panel: Global and region of interest (ROI) data showing significantly lower global and regional cerebral blood flow (CBF) in the TRS compared to the HV group (p < 0.05), without controlling for age or global CBF. Half-violin plots depict the distribution of mean CBF values within each group, boxplots show median and interquartile ranges and circles provide individual values. Right panel: Brain sections illustrating the significant clusters (p < 0.05 family-wise error corrected) of lower CBF in the TRS compared to the HV group, controlling for age and global CBF. ACC anterior cingulate cortex, HV healthy volunteer, TRS treatment-resistant schizophrenia.

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