Fig. 2: Changes in cerebral blood flow in treatment-resistant schizophrenia after 12 weeks of clozapine treatment (N = 24). | Schizophrenia

Fig. 2: Changes in cerebral blood flow in treatment-resistant schizophrenia after 12 weeks of clozapine treatment (N = 24).

From: Response to clozapine in treatment resistant schizophrenia is related to alterations in regional cerebral blood flow

Fig. 2

Left panel: Region of interest (ROI) analysis showing decreased regional CBF in the ACC after 12 weeks of clozapine treatment (*p = 0.01). Half-violin plots depict the distribution of mean ACC CBF at each time point. Circles represent individual values. Right panel: Brain sections illustrating significant clusters (p < 0.05 family-wise error corrected) in whole-brain voxel-wise analyses before (top panel) or after (bottom panel) controlling for changes in global CBF. In both cases, decreased CBF (blue) following clozapine treatment was apparent in a cluster centred on the ACC. After controlling for CBF (bottom panel), a cluster of increased CBF following clozapine treatment was apparent in the left postcentral area (yellow). ACC anterior cingulate cortex, CBF cerebral blood flow, ROI region of interest.

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