Fig. 4: Mitochondrial pathogenesis in schizophrenia.
From: Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk
In response to alterations in the external environment (climate change, fatty diet, stress, drug side effects, heavy smoking and alcohol consumption, radiation, etc.), the human body undergoes oxidative stress at the cellular level and releases excessive reactive oxygen species through the mitochondrial electron transport chain, the NADPH magnesium oxide pathway, and the xanthine oxidase pathway, causing psychiatric and behavioral abnormalities. CoQ coenzyme Q, ETC Electron Transport Chain, NOX NADPH Oxidase, ROS Reactive Oxygen Species, XO Xanthine Oxidase. This figure was drawn by BioRender.
