Table 1 Core guiding principles for selection of AMP SCZ harmonized cognition battery.

From: Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample

Theoretical considerations

 Covers domains relevant to schizophrenia/psychosis

 Covers domains relevant to CHR and outcome prediction

 Assessment of general and specific cognitive abilities

 Incorporates NAPLS “Risk Calculator” tasks

 Sensitive to age and developmental changes

 Timing of assessments for capturing dynamic change

Psychometric considerations

 Repeatable and addresses practice effects

 Reliable and valid

 Avoiding ceiling effects

Practical considerations

 Applicable across different languages and cultures

 Remote administration with standard operating procedures

 Time efficient (minimizes participant burden)

 Computerized administration and scoring

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