Fig. 3: Long-term potentiation (LTP)-like plasticity in the primary motor cortex (M1) across TRS patients, non-TRS patients, and healthy controls. | Schizophrenia

Fig. 3: Long-term potentiation (LTP)-like plasticity in the primary motor cortex (M1) across TRS patients, non-TRS patients, and healthy controls.

From: In vivo assessment of GABAergic inhibition and glutamate facilitation in treatment-resistant schizophrenia: a TMS study integrating clinical, cognitive, and neurophysiological evaluations

Fig. 3

In (A), the time course of motor evoked potential (MEP) amplitude is shown, normalized to the pre-intermittent theta burst stimulation (iTBS) baseline. TRS patients exhibit a marked loss of LTP-like plasticity, as evidenced by reduced MEP amplitude changes over time compared to controls. The arrowheads indicate the timing of the iTBS intervention. B summarizes the overall MEP amplitude changes averaged over the 30-minute post-iTBS period. TRS patients show significantly diminished LTP-like plasticity compared to controls, while non-TRS patients display intermediate responses that fall between those of the other two groups. *Statistically significant for controls vs TRS (p < 0.05). LTP long-term potentiation, LTD long-term depression.

Back to article page