Table 2 Comparison of neurophysiological parameters across groups.

From: In vivo assessment of GABAergic inhibition and glutamate facilitation in treatment-resistant schizophrenia: a TMS study integrating clinical, cognitive, and neurophysiological evaluations

 

HC

Non-TRS

TRS

p value

RMT

Mean ± SD (IQR) (% of MSO)

37.76 ± 6.63 (31.50–41.50)

39.86 ± 10.64 (31.00–45.00)

43.13 ± 10.05 (35.00–50.00)

0.227

AMT

Mean ± SD (IQR) (% of MSO)

30.04 ± 5.01 (25.00–34.00)

31.06 ± 5.91 (27.00–35.00)

35.53 ± 7.55 (31.00–38.00)

0.041

MEP1mV

Mean ± SD (IQR) (% of MSO)

43.90 ± 9.64 (35.50–49.50)

46.46 ± 12.65 (37.00–54.00)

51.93 ± 12.80 (44.00–60.00)

0.137

I (mean SICI)

Mean ± SD (IQR) (% of unconditioned MEP)

33.25 ± 13.63 (21.87–44.95)

48.19 ± 27.55 (25.40–64.34)

67.65 ± 43.31 (24.36–80.82)

0.004

E (mean ICF)

Mean ± SD (IQR) (% of unconditioned MEP)

180.12 ± 46.90 (133.11–218.29)

168.87 ± 63.26 (114.53–194.88)

190.08 ± 76.27 (130.43–242.14)

0.661

EI

Mean (IQR)

1.26 ± 0.18 (1.12–1.41)

1.40 ± 0.19 (1.27–1.55)

1.74 ± 0.74 (1.24–1.88)

0.006

Mean LICI

Mean ± SD (IQR) (% of unconditioned MEP)

18.85 ± 19.93 (4.96–35.02)

23.93 ± 16.44 (4.97–37.78)

16.16 ± 22.65 (3.26–22.92)

0.523

Mean SAI

Mean ± SD (IQR) (% of unconditioned MEP)

52.17 ± 28.23 (32.78–73.40)

68.21 ± 20.19 (55.81–86.62)

72.26 ± 20.22 (67.44–87.27)

0.017

Mean LTP

Mean ± SD (IQR) (% of unconditioned MEP)

160.26 ± 70.83 (118.83–199.16)

131.98 ± 64.73 (86.06–159.26)

116.57 ± 29.54 (96.64–133.24)

0.040

  1. Significance threshold set at p < 0.05. Bold values denote statistically significant results.
  2. HC healthy controls, RMT resting motor threshold, AMT active motor threshold, MEP1mV threshold to obtain 1 mV amplitude MEP, I mean inhibition, SICI short-interval intracortical inhibition, E mean facilitation, ICF intracortical facilitation, EI excitation index, LICI long-interval intracortical inhibition, SAI short-latency afferent inhibition, LTP long-term plasticity.
Back to article page