Table 3 Differences in T cell composition between the SCZ and HC groups.

From: Immunosenescence-related T cell phenotypes, structural brain imaging, and cognitive impairment in patients with schizophrenia: a moderated mediation analysis

%

SCZ

HC

F

pFDR

Cohen’s d

CD4+ cells %

 CD4+

56.08 ± 13.52

53.78 ± 11.86

0.614

0.436

0.18

 CD4 + CD45RA+

39.94 ± 14.33

47.09 ± 13.44

3.578

0.026

–0.51

 CD4 + CD45RO+

59.97 ± 14.28

52.89 ± 13.44

3.449

0.026

0.51

 CD4 + CD95+

72.22 ± 11.68

66.69 ± 11.45

4.173

0.026

0.48

 CD4 + CD45RA + CD95+

22.64 ± 6.65

26.65 ± 7.16

3.495

0.026

–0.58

 CD4 + CD45RO + CD95+

57.41 ± 14.19

49.83 ± 13.69

3.817

0.026

0.54

CD8+ cells %

 CD8+

36.43 ± 10.15

33.85 ± 12.85

1.350

0.291

0.22

 CD8 + CD45RA+

57.25 ± 16.99

67.83 ± 12.80

8.359

0.017

–0.70

 CD8 + CD45RO+

42.65 ± 17.03

32.15 ± 12.80

7.544

0.018

0.70

 CD8 + CD95+

72.90 ± 13.97

69.23 ± 12.43

2.035

0.165

0.28

 CD8 + CD45RA + CD95+

44.70 ± 16.73

52.31 ± 13.48

3.495

0.036

–0.50

 CD8 + CD45RO + CD95+

38.68 ± 16.79

27.91 ± 11.76

8.577

0.017

0.71

 CD4 + /CD8+

1.70 ± 0.85

2.00 ± 1.11

0.818

0.369

-0.30

  1. The percentages of naïve T cell subsets (CD4 + CD45RA + , CD8 + CD45RA + , CD4 + CD45RA + CD95 + , and CD8 + CD45RA + CD95 + T cell subsets) were lower, and the percentages of memory T cell subsets (CD4 + CD45RO + , CD4 + CD95 + , CD4 + CD45RO + CD95 + , CD8 + CD45RO + , CD8 + CD45RO + CD95 + T cell subsets) were higher in patients with SCZ than in HCs. The pFDR was adjusted p value corrected for FDR correction.
  2. SCZ schizophrenia, HC healthy control, FDR false discovery rate correction.
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