Fig. 5: Spatio-temporal gene expression analysis for genes shared between SCZ and peripheral organ imaging phenotypes.

a The spatio-temporal patterns of average gene expression in the whole brain for genes shared between SCZ and peripheral organ imaging phenotypes. The color of the bubbles and lines denotes different organ imaging phenotypes. b–d The spatio-temporal patterns of gene expression in the whole brain for genes shared between SCZ and each group of peripheral organ imaging phenotypes. The x-axis represents the nine developmental windows, and the y-axis represents the log2-transformed and normalized mean expression value. The color of the bubbles and lines denotes different brain regions and neocortical areas. A1C primary auditory cortex, AMY amygdala, CBC cerebellar cortex, CGE caudal ganglionic eminence, CMR cardiac magnetic resonance, DFC dorsolateral prefrontal cortex, DTH dorsal part of the thalamic anlage, DXA dual-energy X-ray absorptiometry, HIP hippocampus, IPC posterior inferior parietal cortex, ITC inferior temporal cortex, LGE lateral ganglionic eminence, M1C primary motor cortex, M1CS1C motor-somatosensory cortex, MD thalamus, MFC medial prefrontal cortex, MGE medial ganglionic eminence, MRI magnetic resonance imaging, MSC motor and somatosensory cortex, OC occipital cortex, OFC orbital prefrontal cortex, PC parietal cortex, PCW post-conception week, PY postnatal year, S1C primary somatosensory cortex, SCZ schizophrenia, STC posterior superior temporal cortex, STR striatum, TC temporal cortex, URL upper (rostral) rhombic lip, V1C primary visual cortex, VFC ventrolateral prefrontal cortex.