Fig. 6: Drug-target enrichment analysis and gene-drug interactions.
From: The shared genetic architecture between schizophrenia and common peripheral organ imaging phenotypes
a The significant results (Fisher’s Exact Test P < 0.05) of drug-target enrichment analyses based on shared genes between SCZ and peripheral organ imaging phenotypes using GREP. The bar chart depicts the odds ratios (ORs) of various drug groups across three organ groups of imaging phenotypes (CMR phenotypes, skeletal DXA phenotypes, and abdominal MRI phenotypes). Each drug group is distinguished by a unique color. b–d The bubble plots illustrated the drug-gene interactions for genes shared between SCZ and three organ groups of imaging phenotypes (CMR phenotypes, skeletal DXA phenotypes, and abdominal MRI phenotypes) using the DGIdb. The x-axis represents drug names, the y-axis indicates drug categories, and the size of the bubbles reflects the drug-gene interaction group score, a quantitative measure of the strength or significance of the interactions. The color of the bubbles denotes different drug-gene interaction types. CMR cardiac magnetic resonance, DGIdb the Drug Gene Interaction Database, DXA dual-energy X-ray absorptiometry, GREP the Genome for REPositioning Drugs, MRI magnetic resonance imaging, RAS renin-angiotensin system, SCZ schizophrenia.
