Fig. 2: Effects of Met supplementation on anxiety and working memory in subacute aging mice.

A OFT diagram (anxious mice will move less into the central area and more along the wall), B total distance in the OFT, C entries to the central area in the OFT, D time spent in the central area in the OFT, E distance in the central arear in the OFT, F EPMT diagram (anxiety mice will less enter the open arms), G entries to the open arms in the EPMT, H time spent in the open arms in the EPMT, I Y-maze test diagram, J spontaneous alternation. ND: saline + normal diet; D + ND: D-Gal + normal diet; D + MS: D-Gal + Met supplementation. Data are represented as mean ± SEM (n = 10). “ns” means not significantly different; ***p < 0.001, versus ND; #p < 0.05, ##p < 0.01, versus D + ND.