Fig. 8: Effects of Met supplementation on the accumulation of cognitive toxins and cognition-related pathways in the hippocampi in subacute aging mice. | npj Science of Food

Fig. 8: Effects of Met supplementation on the accumulation of cognitive toxins and cognition-related pathways in the hippocampi in subacute aging mice.

From: Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice

Fig. 8

A AGEs, B lipofuscin, and C Aβ-40 levels in the hippocampi, D the relative mRNA expression levels of NF-κB, Nrf2, HO-1, NQO-1, Bcl-2, caspase3, and Bax in the hippocampi, E the relative mRNA expression levels of BDNF, TrkB, RC3, Gap-43, PSD-95, and SYNAPO in the hippocampi, F the relative mRNA expression levels of Nr1, Nr2a, Nr2b, CAMK2A, CAMK2B, and CAMK2D in the hippocampi, G, H the protein expression levels of P-NF-κB p65, NF-κB p65, BDNF, Nr2b, P-CAMK2, and CAMK2 in the hippocampi. ND: saline + normal diet; D + ND: D-Gal + normal diet; D + MS: D-Gal + Met supplementation. Data are represented as mean ± SEM (n = 8 or 6 or 3). “ns” means not significantly different; *p < 0.05, **p < 0.01, ***p < 0.001, versus ND; #p < 0.05, ##p < 0.01, ###p < 0.001, versus D + ND.

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