Table 1 Standard curve equations, recovery rates, precision rates, LODs, and LOQs of probe substrates in vitro detected through HPLC
From: Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats
Probe substrate | Standard curve | Concentration (mg/L) | Recovery (%) | Precision (%) | LOD (mg/L) | LOQ (mg/L) |
|---|---|---|---|---|---|---|
Dapsone | y = 92.773x + 1.646, R2 = 0.998 | 4.00 | 91.57 | 2.82 | 0.0205 | 0.0410 |
2.00 | 89.73 | 2.44 | ||||
1.00 | 88.50 | 2.13 | ||||
Phenacetin | y = 83.514x-0.712, R2 = 0.9996 | 4.00 | 89.17 | 2.38 | 0.0195 | 0.0390 |
2.00 | 89.53 | 3.62 | ||||
1.00 | 92.55 | 3.76 | ||||
Omeprazole | y = 99.321x-0.452, R2 = 0.9996 | 4.00 | 91.93 | 2.91 | 0.0390 | 0.0780 |
2.00 | 87.77 | 3.16 | ||||
1.00 | 93.47 | 1.78 | ||||
Chlozoxazone | y = 23.864x–0.125, R2 = 0.998 | 4.00 | 87.90 | 2.07 | 0.0460 | 0.0900 |
2.00 | 90.43 | 3.11 | ||||
1.00 | 88.93 | 5.18 | ||||
Dextromethorphan | y = 41.475x + 1.646, R2 = 0.998 | 4.00 | 90.40 | 4.12 | 0.0200 | 0.0333 |
| Â | Â | 2.00 | 86.30 | 3.33 | Â | Â |
| Â | Â | 1.00 | 89.47 | 4.51 | Â | Â |
