Table 4 Pharmacokinetic parameters of DHA-Na in rats after administration of specific inhibitors
From: Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats
Drug | Group | t1/2 (h) | Cmax (mg/L) | Tmax (h) | AUC(0-t) (mg/L*h) | AUC(0-∞) (mg/L*h) | MRT (h) | Vd (L/kg) | CL (L/h/kg) |
|---|---|---|---|---|---|---|---|---|---|
Control | ♂ | 9.21 ± 1.25# | 219.81 ± 17.45# | 0.94 ± 0.20 | 2791.41 ± 131.86# | 3460.46 ± 352.48# | 7.29 ± 0.23# | 0.80 ± 0.094 | 0.059 ± 0.005# |
♀ | 10.66 ± 0.79 | 245.24 ± 8.76 | 1.06 ± 0.11 | 3190.04 ± 145.44 | 4098.26 ± 244.22 | 8.01 ± 0.23 | 0.76 ± 0.030 | 0.050 ± 0.003 | |
Furafylline | ♂ | 11.17 ± 0.85*# | 242.43 ± 9.54**# | 1.00 | 3284.34 ± 111.79**# | 4141.30 ± 222.12**# | 7.87 ± 0.21**# | 0.74 ± 0.048 | 0.048 ± 0.003**# |
♀ | 11.91 ± 0.91* | 264.15 ± 12.88** | 1.06 ± 0.11 | 3574.03 ± 146.79** | 4792.41 ± 232.28** | 8.18 ± 0.15* | 0.68 ± 0.062* | 0.040 ± 0.004** | |
Ketoconazole | ♂ | 9.45 ± 0.88# | 247.69 ± 14.79**# | 1.00 | 3163.13 ± 127.67**# | 3856.30 ± 315.93*# | 7.42 ± 0.26# | 0.71 ± 0.040* | 0.053 ± 0.004*# |
♀ | 11.84 ± 1.52* | 268.30 ± 15.42** | 1.06 ± 0.11 | 3583.16 ± 203.01** | 4906.74 ± 364.37** | 8.24 ± 0.30* | 0.67 ± 0.063* | 0.039 ± 0.006** | |
Ticlopidine | ♂ | 9.90 ± 0.60 | 213.89 ± 13.12# | 0.80 ± 0.24 | 2800.27 ± 232.69# | 3513.06 ± 377.20# | 7.51 ± 0.26# | 0.87 ± 0.13 | 0.053 ± 0.008 |
♀ | 10.24 ± 1.75 | 245.66 ± 15.55* | 1.00 | 3204.44 ± 188.76 | 4193.52 ± 448.68 | 7.92 ± 0.60 | 0.80 ± 0.177 | 0.048 ± 0.006 | |
Quinidine | ♂ | 11.02 ± 1.61* | 246.27 ± 16.46** | 1.22 ± 0.35 | 3474.97 ± 164.28**# | 4488.85 ± 424.35**# | 7.93 ± 0.37** | 0.68 ± 0.083* | 0.044 ± 0.005**# |
♀ | 11.91 ± 0.91* | 264.15 ± 12.88** | 1.06 ± 0.11 | 3574.03 ± 146.79** | 4792.41 ± 232.28** | 8.18 ± 0.15 | 0.68 ± 0.062* | 0.040 ± 0.004** | |
Clomethiazole | ♂ | 10.13 ± 0.77 | 214.79 ± 13.72# | 0.99 ± 0.25 | 2792.21 ± 162.85# | 3305.14 ± 260.16# | 7.32 ± 0.20# | 0.86 ± 0.059# | 0.054 ± 0.007# |
♀ | 11.05 ± 1.04 | 230.42 ± 15.88 | 1.06 ± 0.10 | 3157.87 ± 130.53 | 4058.44 ± 232.93 | 8.15 ± 0.35 | 0.78 ± 0.061 | 0.049 ± 0.003 |
