Table 3 Library of the top 10 TR interactions overall

From: Unravelling the human taste receptor interactome: machine learning and molecular modelling insights into protein-protein interactions

TR interaction (UID)

Gene1

Gene2

Probability score

Aff predictions (kJ/mol)

Mean Prob—Scaled Aff

iRefIndex check

P0C0E4-P59551

RAB40AL

TAS2R60

0.99

38.90

0.70

0

A1A580-Q7RTM1

KRTAP23-1

OTOP1

0.98

38.90

0.69

0

P37088-P51170

SCNN1A

SCNN1G

0.98

38.04

0.69

0

P05771-P41180

PRKCB

CASR

0.98

38.04

0.69

1

P59540-Q9NY47

TAS2R46

CACNA2D2

0.97

38.04

0.68

0

Q92556-Q9NYW3

ELMO1

TAS2R7

0.98

37.19

0.68

0

P49753-Q13255Β

ACOT2

GRM1

0.97

38.04

0.68

0

Q8WYK1-Q9NYW5

CNTNAP5

TAS2R4

0.97

38.04

0.68

0

P37088-Q9NRS4

SCNN1A

TMPRSS4

0.98

37.19

0.68

0

P21439-Q7RTM1

ABCB4

OTOP1

0.97

38.04

0.68

0

  1. “TR interaction (UID)”: taste receptor interaction’s Uniprot IDs, Gene1/ Gene2: taste receptor interaction’s gene names, predicted classes: indication of the positive class prediction (1), “iRefIndex check”: 1 if the interaction has been recorded in iRefIndex, 0 if not, probability score: the classifier’s prediction probability score, “Aff predictions”: the binding strength (affinity) predictions of the regressor in absolute ΔG values, “Mean Prob—Scaled Aff”: the mean of classifier’s prediction probability score and the predicted binding strength in 0–1 scale.
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