Table 1 Pathway enrichment analysis results for differentially abundant metabolites in Caco-2 cells
Serial number | Primary access | Secondary access | Pathway description | P value | Number of key metabolites |
|---|---|---|---|---|---|
1 | Environmental Information Processing | Signal Transduction | cGMP-PKG signaling pathway | 0 | 4 |
2 | Metabolism | Global and overview diagrams | Nucleotide Metabolism | 0 | 10 |
3 | Metabolism | Nucleotide Metabolism | Purine Metabolism | 0 | 13 |
4 | Human Diseases | Cancer: Overview | Choline metabolism in cancer | 0 | 4 |
5 | Metabolism | Global and Overview Charts | Cofactor biosynthesis | 0 | 15 |
6 | Organismal Systems | Sensory Systems | Taste transduction | 0 | 6 |
7 | Human Diseases | Drug Resistance: Antitumor Agents | Antifolate Resistance | 0.0001 | 4 |
8 | Organismal Systems | Endocrine System | Renin secretion | 0.0001 | 4 |
9 | Organismal Systems | Endocrine System | Aldosterone synthesis and secretion | 0.0002 | 4 |
10 | Living organism system | Aging | Lifespan regulatory pathways | 0.0002 | 3 |
11 | Organism system | Sensory system | Olfactory conduction | 0.0002 | 3 |
12 | Human Diseases | Substance dependence | Morphine addiction | 0.0002 | 3 |
13 | Human Disease | Cardiovascular Disease | Diabetic cardiomyopathy | 0.0002 | 5 |
14 | Human Disease | Cancer: An Overview | Central carbon metabolism in cancer | 0.0002 | 5 |
15 | Organism system | Environmental Adaptation | Thermogenesis | 0.0003 | 4 |
16 | Human Diseases | Endocrine Metabolic Diseases | Alcoholic Liver Disease | 0.0004 | 3 |
17 | Organism System | Endocrine System | Glucagon signaling pathway | 0.0005 | 4 |
18 | Human Diseases | Neurodegenerative Diseases | Parkinson’s Disease | 0.0005 | 4 |
19 | Organism system | Digestive System | Bile secretion | 0.0005 | 7 |
20 | Organism system | Endocrine System | Regulation of adipocyte lipolysis | 0.001 | 3 |
