Fig. 1 | npj Systems Biology and Applications

Fig. 1

From: On the performance of de novo pathway enrichment

Fig. 1

A typical workflow for de novo pathway enrichment. The underlying hypothesis is that phenotype-specific genes (foreground, FG) are differentially expressed in many case samples compared to a control group (1, 2) By using statistical tests, one can determine which genes are affected by the phenotype (3) and overlay this information on an interaction network (4) De novo pathway enrichment tools aim to extract sub-networks enriched with phenotype-specific FG genes (5) Comparing several such methods is an open issue

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