Fig. 4

Differential consensus module eigengene analysis. Differential eigengene network analysis between rat and human consensus module eigengene networks was used to define the strength of the correlation preservation for all eigengene pairs across the two networks: a, b Clustering dendrograms of consensus module eigengenes (me) demonstrates the presence of meta-modules M1–M3 (thick horizontal bars) across both species; the same three major branches are found in both dendrograms. c, d Heatmap plots of eigengene adjacencies for each of the eigengene networks (c, rat; d, human). Each of the rows and columns indicate an eigengene labeled by the consensus module color. Red indicates high adjacency (positive correlation), while blue indicates the inverse, as depicted by the color legend. e Bar plot of the preservation of the consensus eigengene relationships between the two networks. Each bar represents the eigengene of the associated consensus module; the eigengene preservation measure is given by the height of the bar (y-axis). The high-density value D(Preserv^human,rat) = 0.85 reflects the high overall preservation between the two networks, i.e., correlation preservation is high between all pairs of eigengenes across the two networks. f Adjacency heatmaps for the pair-wise preservation network Preserv^human,rat; high values of Preserv^human,rat indicate correlation preservation between pairs of module eigengenes is strong across the two networks. Each consensus module eigengene is represented by the rows and columns, with the level of red saturation indicating adjacency according to the color legend. Overall, the M2 meta-module in both species, derived from C4 and C5 eigengenes, are the most highly correlated. The C3 and C4 modules represented the most highly preserved eigengenes