Fig. 1 | npj Systems Biology and Applications

Fig. 1

From: Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome

Fig. 1

a The workflow of the analysis steps. As it has shown, we have reconstructed the secretory pathway network including different subsystem. In parallel, we have defined human secretome integrating the post-translational modifications (PTMs) information obtained from UniProt. Two independent transcriptome data including HPA and GTEx data sets were used for the meta-analysis to define the tissue-specific secretome and secretory pathways. b The properties of the general secretory pathway network. The secretory pathway network has 575 core components that are accommodated in four main functional modules and 13 subsystems. The complex column represent the number of the protein complexes in each subsystem. The secretory column shows the number of components that are the clients of the secretory pathway

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