Fig. 2 | npj Systems Biology and Applications

Fig. 2

From: Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome

Fig. 2

Expression of the secretory pathway and its clients across human tissues. a The frequency of the different expression categories of human secreted or membrane protein-encoding genes based on GTEx and localization information. Only protein with N-terminal signal peptide is included. Proteins were grouped according to localization. From this set, 503 proteins are localized in the lumen or the membrane of the ER and Golgi which encompass a large part of the secretory pathway components. b Shows the hierarchical clustering of cross-tissue correlation coefficients for the expression of secretory pathway genes in the “tissue-elevated” and “expressed in all” category (see the Methods for definition). The heatmap of the clustering for 30 human tissue pairwise correlation (Pearson correlations) is based on the expression profiles of 575 secretory pathway genes. The color code for correlation is depicted next to the heatmap

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