Fig. 2
From: Predicting ligand-dependent tumors from multi-dimensional signaling features
Structure of computational signaling model. a The receptors EGFR, HER2, ErbB3, Met, and IGF-1R can form several homo and heterodimers after ligand binding. b In the model, receptors are synthesized and either dimerize spontaneously or bind a ligand to form homo- and hetero-dimers, which results in trans-phosphorylation of the receptors. Activated receptors signal downstream and are prone for internalization, which leads to either degradation or dephosphorylation by a phosphatase followed by recycling to the cell surface. Downstream, the MAPK and PI3K cascade activate S6K1 and ultimately converge in the phosphorylation of S6. The MAPK and PI3K signaling pathways are interconnected via multiple crosstalk mechanisms
