Fig. 3
From: Predicting ligand-dependent tumors from multi-dimensional signaling features
Importance of receptor surface levels for model response, shown for a selection of calibration cell lines. a Cell line dependent signaling features: Model response to EGF stimulation of two different cell lines resulting in sustained or transient receptor phosphorylation in the BxPc-3 and IGROV-1 cells. Their respective receptor surface levels are shown on the left. The model fits are represented by the colored lines with respective uncertainties (67% confidence intervals) as shades. Data points are shown as dots in the same color. b Model fits for the cell line ACHN stimulated with HGF, EGF and the combination. c Model response to co-stimulation of EGF plus HRG in comparison to the stimulation with EGF, HRG or IGF-1 alone in H322M cells
