Fig. 6
Predicted input function of an alternative genetic implementation of the mar dual autoregulatory motif. a Schemes of two possible genetic implementations of the mar core network with positive and negative autoregulation (in the absence of Rob and CRP:cAMP).58 Left scheme correspond to the natural circuit. Right scheme corresponds to the hypothetical circuit where the oxidized MarR works as an activator (with competitive binding). b Input function (model simulations of normalized promoter activity relative to the maximum) with respect to salicylate. Solid line denotes the natural circuit (input and output range being R in = 27.51 and R out = 7.17, respectively). Dashed line denotes the hypothetical one (R in = 5.16 and R out = 62.17). Inset shows the associated response times (time to reach steady state) of these two implementations. Black bars correspond to the natural circuit. Hatched bars to the hypothetical circuit (gray bar shows a null reference value relative to a system that would start the production of the mar operon at a constant rate). Low dose corresponds to 0.01 mM and high dose to 10 mM
