Fig. 9 | npj Systems Biology and Applications

Fig. 9

From: Integrative gene network analysis identifies key signatures, intrinsic networks and host factors for influenza virus A infections

Fig. 9

DOCK5 is a key regulator for splicing and transport. Virus entry and initial transport to the nucleus is shown with regulatory links to the spliceosome, intracellular trafficking, and control of budding. In particular, CD81 potentially controls both entry/initial transport as well as budding. DOCK5 causally influences the V-type ATPases and CLINT1 with respect to transport, as well as NS1 BP, potentially for splicing. As a RAC specific GEF, DOCK5 transduces signals for cytoskeleton rearrangement as a host defense response against IAV infection. DOCK5 also down-regulates splicing by directly modulating hnRNPA1, NS1 BP, and SYNCRIP as well as SF3A1/SF3B1 and DHX36, in addition to down-regulation of NUP93 and NUP210. Blue colored nodes are down-regulated by DOCK5. Green nodes are in the DOCK5-CCGS(7) neighborhood but not causally controlled by DOCK5. Closely spaced nodes indicate protein–protein interaction, black solid lines are material transport, blue dashed lines indicate DOCK5 induced gene regulation, solid red lines denote induced functions based on published studies (see text)

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