Fig. 6

VEGFR1 preferentially activates PLC_γ, PI3K, and Src, possibly to form a Ca²⁺ signaling regulatory loop. Our simulations predict that VEGFR1 tyrosine sites are structured to preferentially associate with PLC_γ or PI3K at Tyr⁷⁹⁴ and Src at Tyr¹¹⁶⁹ or Tyr¹²¹³, simultaneously, as portrayed. We theorize that this PLC_γ, PI3K, and Src activation scheme by VEGFR1 forms a Ca²⁺ signaling regulatory loop, as depicted. Arrow color indicates adapter or Ca²⁺ signal activation by VEGFR1 (solid gray), PLC_γ (blue), PI3K (pink), Src (cyan), or through Ca²⁺ signaling (dashed gray). Additional VEGFR1-binding sites and adapter association are not shown