Table 2 Interactome-based proximity from sGC subunits to various disease phenotypes

sGC subunit^a	Stroke	Disease	Z^b	p-value^c
All		Vision disorders	−3.405	0.00033
		Varicose veins	−3.135	0.00086
		Esophageal disease	−3.001	0.00134
		Spinocerebellar ataxias	−2.995	0.00137
		Asthma	−2.787	0.00266
		Head and neck neoplasms	−2.725	0.00321
	*	Stroke	−2.698	0.00348
		Retinitis pigmentosa	−2.279	0.01132
		Diabetes mellitus type 2	−2.122	0.01691
α-1		Vision disorders	−3.711	0.00010
		Varicose veins	−3.239	0.00060
		Esophageal disease	−2.959	0.00154
		Spinocerebellar ataxias	−2.741	0.00307
		Head and neck neoplasms	−2.529	0.00572
		Asthma	−2.494	0.00631
	*	Stroke	−2.288	0.01106
		Retinitis pigmentosa	−1.923	0.02727
		Diabetes mellitus type 2	−1.778	0.037678
α-2^d		Vision disorders	−2.383	0.00859
		Spinocerebellar ataxias	−2.356	0.00923
	*	Stroke	−2.289	0.01105
		Varicose veins	−2.240	0.01255
		Esophageal disease	−2.238	0.01263
		Asthma	−2.217	0.01330
		Head and neck neoplasms	−2.127	0.01672
		Retinitis pigmentosa	−2.108	0.01751
		X-linked mental retardation	−2.080	0.01874
β-1^e		Vision disorders	−2.387	0.00848
	*	Stroke	−2.339	0,00966
		Asthma	−2.291	0.01097
		Varicose veins	−2.270	0.01162
		Spinocerebellar ataxias	−2.266	0.01172
		Head and neck neoplasms	−2.225	0.01302
		Esophageal disease	−2.199	0.01394
		Retinitis pigmentosa	−2.041	0.02062
		Diabetes mellitus type 2	−1.931	0.02671

^a sGC is an heterodimer requiring both one α and one β subunit
^b For each protein and diseases, the proximity quantifies the significance of closeness of the set of proteins to the disease-genes, producing negative z-scores for protein–disease pairs that are closer in the interactome compared to random expectation
^c The p-value was calculated using the proximity score (z), corresponding to the probability that a randomly selected protein having the same degree in the interactome as the protein of interest would be at least as close to the disease genes than the observed distance in the interactome
^d For stroke (annotated as cerebrovascular disease in MeSH), α₂-subunit, which is predominantly expressed in neurons has the third highest score
^e The active β₁ subunit has the second highest score

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