Fig. 3

Visualization of epigenomic and transcriptional cooperation illustrates redundancy and complexity of a target network. a Hierarchical trees of human transcription factors correspond to transcription factor superclass, class, and family from inward out. Transcription factor motifs often get recognized by multiple members of the same transcription factor family due to structural homology of DNA binding domains. The transcription factor target analysis (TFT) is carried out on sequence-specific epigenomics data. b Size of the transcriptional effector network and the direction of response are key parameters when evaluating target genes in epigenomic cooperation. The TFT analysis is based on differentially expressed transcripts with transcriptomic up and down response in red and blue, respectively. c Transcription factor target networks provide insight into enrichment and direction of the response. Identified cooperating transcription factors show agreement between complementary data of expression levels, direction of regulation, target sets, and hierarchical linkage