Fig. 4
Network of transcriptional cooperation of an epigenomic master regulator visualized by transcription factor family trees. a A network of transcription factors is detected using complementary epigenomic and transcriptomic data. The realm of potentially relevant transcription factor families is large yet many data points are not mirrored or validated by different platforms. b, c Confidence and mutual data support increases by integrating analysis of motif enrichment (AME), transcription factor target analysis (TFT), or up-stream regulator analysis (URA). For each data source B chromatin modifications or c differential expression of target genes detected transcription factors supported by at least two complementary techniques, AME and TFT for epigenomics data, and URA and TFT for transcriptomics. d High-confidence target network of transcription factors validated by four different omics platforms integrating ChIP-Seq based motifs and transcriptional networks. Legends of colored areas in Venn diagrams illustrate intersections of complementary datasets and analysis platforms with numbers of identified transcription factor families, respectively. The numbers next to individual nodes of the hierarchical family tree indicate transcription factor superclass, class, and family from inward out
