Table 1 Detection of transcriptional cooperation by multi-omics integration of complementary data and analysis techniques
Symbol | Motif | TFClass | TF family | ChIP-Seq AME pval | ChIP-Seq TFT pval | Transcriptomics URA pval | Transcriptomics TFT pval |
|---|---|---|---|---|---|---|---|
JUN | TGAGTCA | 1.1.1 | Jun-related factors | 2.85E−16 | 1.55E−18 | 2.46E−03 | 2.40E−17 |
CEBPB | ATTGC GCAAT | 1.1.8 | C/EBP-related | 4.04E−40 | 5.58E−09 | 0.00E+00 | 6.38E−09 |
MYOD | CAGGTG | 1.2.2 | MyoD / ASC-related factors | 1.35E−38 | 6.97E−18 | 4.28E−02 | 6.36E−19 |
HIF1A | CACGC | 1.2.5 | PAS domain factors | 1.88E−179 | 3.10E−02 | 0.00E+00 | 4.54E−17 |
SREBF1 | CACATG | 1.2.6 | bHLH-ZIP factors | 1.14E−46 | 1.76E−08 | 3.81E−02 | 1.64E−12 |
MYC | CACATG | 1.2.6 | bHLH-ZIP factors | 9.41E−67 | 6.24E−21 | 1.97E−02 | 6.46E−31 |
AR | AGAACANNNTCTTGT | 2.1.1 | Steroid hormone receptors NR3 factors | 1.02E−03 | 2.71E−02 | 3.30E−02 | 1.15E−02 |
SP1 | CACCC | 2.3.1 | Three-zinc finger Krüppel-related factors | 4.04E−190 | 2.40E−63 | 5.19E−03 | 9.68E−87 |
MEIS1 | TGACA | 3.1.4 | TALE-type homeo domain factors | 1.90E−04 | 6.26E−15 | 7.61E−03 | 7.37E−12 |
ZEB1 | CACCTG | 3.1.8 | HD-ZF factors | 1.02E−111 | 4.37E−18 | 2.88E−02 | 6.24E−19 |
ELK1 | GGAAG | 3.5.2 | Ets-related factors | 1.97E−03 | 1.43E−13 | 2.84E−02 | 1.78E−24 |