Table 2 Epigenomic and transcriptional cooperation events in cancer. Original findings and reported cooperation events of epigenomic regulators with transcription factor are enumerated

JUN

1.1.1

KDM3A assists in recruiting JUN to AP1 binding sites in regulating expression of CD44, MMP7, and PDGFRB in liver adenocarcinoma tumor formation

⁵¹

KDM4A promotes a positive feedback loop by facilitating the binding of the AP1 complex to the promoters JUN and FOSL1 in squamous cell carcinoma cells

⁵²

CEBPB

1.1.8

Novel event

KDM4B serves as a cofactor for CEBPB in preadipocytes and is recruited to the promoters of CEBPB regulated cell cycle genes

⁵³

MYOD

1.2.2

Novel event

KDM4B regulates the expression of MYOD and physically interacts with MYOD thereby controlling myogenic differentiation

⁵⁴

KDM4C decreases MYOD degradation and increase MYOD transcriptional activity to facilitate skeletal muscle differentiation

⁵⁵

HIF1A

1.2.5

KDM3A expression is stimulated by HIF1A binding to a response element in the promoter region of KDM3A

²⁴

KDM3A is regulated by HIF1A stimulating tumor formation in renal cell carcinoma

²²

KDM3A cooperates with HIF1A to induce glycolytic genes in urothelial bladder carcinoma

²⁵

SREBF1

1.2.6

Novel event

KDM1A regulates SREBF1 binding to the FASN promotor stimulating lipogenesis

²⁶

MYC

1.2.6

KDM3A stimulates MYC expression and attenuates its ubiquitin-dependent degradation by binding to a E3 ubiquitin ligase

⁵⁶

KDM3A regulates transcription of MYC and PAX3 by directly binding to their promotors and regulates their H3K9me₂ level in breast adenocarcinoma

⁵⁷

KDM4B binds the MYC/MAX motif and regulates expression of MYC signaling in neuroblastoma

⁵⁸

N-MYC physically interacts and recruits KDM4B. Additionally KDM4B is able to regulate the expression of MYC signaling in neuroblastoma

⁵⁸

AR

2.1.1

KDM3A regulates the transcriptional program of the AR, serves epigenomic master regulator by epigenomic and transcriptional cooperation of prostate adenocarcinoma

⁵

KDM3A facilitates transcriptional activation by hormone-dependent recruitment of the AR to target genes in prostate adenocarcinoma

¹⁴

KDM1A and KDM4D bind to the AR and localize to ARE half sites in the promoter region of VEGFA in placental development

²¹

KDM4A binds the AR and supporting urothelial bladder carcinoma initiation and progression

⁵⁹

KDM4B enhances AR transcriptional activity by demethylation and inhibits ubiquitination of the AR

⁶⁰

SP1

2.3.1

Novel event

KDM4A silences SP1 by chromatin demethylation in breast adenocarcinoma

⁶¹

MEIS1

3.1.4

Novel event

ZEB1

3.1.8

Novel event

ELK1

3.5.2

Novel event