Fig. 5

Simulations of spatiotemporal evolution of HT1080 cells using experimentally fitted model C. a The total numbers of cells in time (simulation in solid lines and experimental data in dashed lines with error bars). Note that this time, we kept the simulation time to 12 steps so that we cover at least two time points for every cell cycle of ~ 24 h. That is, each simulation step corresponds to 12 h or half cell cycle. b The total numbers of cells in time with model parameters individually fitted to each condition. The parameters for rules (i) 4 (WT), 1 (TRAIL, TR + BIS), (ii) 9 (WT), 5 (TRAIL, TR + BIS), and (iii) 5–8 (WT), 4 (TRAIL), 2–4 (TR + BIS). Simulation in solid lines and experimental data in dashed lines with error bars. c 2-D top view of the simulations in b. d The proportion of epithelial e over mesenchymal (M) cells in time. Simulation in solid lines and experimental data (Table 1) in dashed lines with error bars