Fig. 6 | npj Systems Biology and Applications

Fig. 6

From: Simulation of heterosis in a genome-scale metabolic network provides mechanistic explanations for increased biomass production rates in hybrid plants

Fig. 6

Multi-locus relaxation of bottlenecks in the chorismate pathway in an F1 hybrid. The right side of the figure represents a section of the chorismate biosynthetic pathway. On the left, the boxplots show the differences between enzyme capacity and computed flux for these four steps in the pathway. At the bottom, the boxplots show the efficiency of the pathway in the three populations. The data are from a collection of F1 hybrids and their parents (ParentA, ParentB). In the inbred parents, the fluxes through two reactions (EC 4.2.3.4 and EC 4.2.1.10) are limited by particularly low enzyme capacities. These bottlenecks reduce the activity of the upstream and downstream reactions. In the resulting F1 hybrids, the additive effect of the two alleles partially complements each of the two bottlenecks, resulting in a greater average efficiency for the pathway as a whole. In this simple example, relaxation of the metabolic bottleneck primarily only involved two loci; in most cases, the interactions are more complicated to unravel

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