Fig. 4 | npj Systems Biology and Applications

Fig. 4

From: An unconventional uptake rate objective function approach enhances applicability of genome-scale models for mammalian cells

Fig. 4

Demonstration of biomass objective function (BOF) and uptake-rate objective functions (UOFs)-based predictions versus experimental measurements for for CHO cells during early and late exponential phases. a Schematics of the BOF and UOFs inputs and outputs when applied to CHO genome-scale model; b growth rate predictions via BOF using three cell-line specific models and metabolomics datasets for fed-batch of CHO-DG44-derived cell line,9 for early and late exponential phases; c uptake rate predictions of glucose and 5 non-essential amino acids and measurements obtained via UOFs for these same datasets

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