Fig. 3

Four stress-activated modules. We selected the four modules with the highest fraction of upregulated genes with physical interactions. Here, we show the NOA rewiring hubs with their first-level interactors. The modules are enriched for cell stress maintenance functions such as DNA double-stranded break repair, stress response, chromatid segregation and DNA replication regulation. The sizes of the nodes are the number of differential modules that the gene is part of across cancer types. Grey nodes indicate that these genes were not significantly differentially expressed. a Brain module 1. b Kidney-Papillary module 1. c Lung-Adeno module 1. d Uterus module 1. e LogFC: Log₂ fold change