Fig. 4

Global parameter sensitivity analysis. Global sensitivity analysis was performed by varying all model parameters simultaneously and performing partial rank correlation analysis to find the effect of inputs (total protein abundance and reactions rates) on the model outputs of interest, primarily phosphorylation of Akt and ERK (extracellular-regulated kinase) at 120 min (a). Only the parameters with significant effect (p < 0.01) are shown in a. Furthermore, the effect of parameters on a larger set of model outputs was explored (b) that illustrates localization of parameters that affect the Met receptor dynamics and also crosstalk between the Akt and ERK arms of the pathway. Magnitude of partial rank correlation coefficients (PRCCs) are shown for output parameters and specified at two time points of 15n and 120 min (b). All PRCCs are based on the number of molecules per cell as output and only the significant (p < 0.01) PRCCs have non-zero values in the heatmap (b). Itg in the list of species and parameter names refers to α5β1 integrin