Fig. 2
From: Genetic interaction networks mediate individual statin drug response in Saccharomyces cerevisiae
Primary genetic interaction networks and functional annotation illustrates variation across genetic backgrounds. a, b Chemical genetic profile for atorvastatin (a) and cerivastatin (b) showing interactions shared by different genetic backgrounds (purple, green and blue) or interactions unique to specific genetic backgrounds (yellow, genes not included in this figure). c Spatial analysis of functional enrichment (SAFE) of 20 GINs derived from five queries (atorvastatin, cerivastatin, hmg1-Δ, hmg2-Δ, arv1-Δ) and four genetic backgrounds (S288C, UWOPS87-2421, Y55, YPS606). Relative to the 18 functional regions previously defined,13 the figure illustrates significant membership of each GIN to these functional regions where the intensity of the colour is proportional to the number of interactions
